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Newer PDE5 inhibitors like Cialis, Levitra, and Stendra offer some distinct advantages. Cialis (tadalafil) has a longer duration of action, lasting up to 36 hours, which provides a wider window for sexual activity. Levitra (vardenafil) has a similar onset to Viagra but may work better for some men with certain health conditions. Stendra (avanafil) boasts a rapid onset of action, often working in just 15 minutes, and is less likely to interact with food.